Filament tracing and editing
Network analysis of neurons and other filamentous structures is of great interest to study and understand the morphology and remodeling capabilities of such networks. This further helps to create a greater understanding of brain functionality and disease impact and treatment.
With Amira Software, our customers are able to trace, analyze and quantify 3D images of filamentous structures such as neurons, blood vessels and microtubules. Filamentous networks can be reconstructed, and measures such as length, thickness, orientation, ranks, etc. can be computed and visualized in compelling 3D renderings. Tracing can be performed automatically or interactively, depending on the application and needs. Our template matching algorithm allows automatic detection and tracing of fine filaments in noisy CryoEM data. Amira Software also enables scientists to edit the resulting graphs to remove image feature erroneously identified as a filament, or add missing parts of a network.
The Max Planck Institute of Neurobiology uses Amira Software for axon tracing.