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Transmission Electron Microscopes

Talos F200C TEM for Life Sciences

Industry-leading power and versatility for 3D imaging of molecules and cells

The Thermo Scientific™ Talos™ F200C transmission electron microscope (TEM) is a powerful, versatile system for delivering 3D characterization of biological and biomaterials samples in cell biology, structural biology, and nanotechnology research. With its innovative design to increase throughput, stability, and ease of use, the Talos F200C TEM enables scientists to quickly obtain better insight and understanding of macromolecular structures, cellular components, cells, and tissues in three dimensions.




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High Resolution for 3D Insight

The Talos F200C TEM’s constant-power, C-TWIN lens delivers outstanding optical performance to help ensure an optimal balance between contrast and resolution.

Talos F200C TEM Benefits for Life Science

Support a wide range of users. The Talos F200C TEM enables a wider range of users to access powerful 3D characterization capabilities for biological and biomaterials samples with a fully digital interface, class-leading ergonomics, and remote control features.
Get results faster. Extended automation combined with a fully integrated 16-Megapixel CMOS detector reduces the number of required steps.
Improve repeatability and reliability. A constant-power objective lens, (optional) Piezo stage, highly stable optics, and a robust system enclosure deliver maximum system stability.
Do more on one system. Perform the widest range of applications from a single platform.


 

Featured Document

Talos F200C TEM Datasheet

The Talos F200C is a 200kV Transmission Electron Microscope (TEM), designed for cryo and room temperature applications. It supports multiple automated imaging applications, such as tomography and single particle analysis (SPA), on both vitrified and ambient suspensions, cell organelles, and cells.

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Publication list for Talos for Life Sciences

Title: Achieving Better Than 3 Å Resolution By Single Particle Cryo-EM At 200 keV
Authors: Herzik, M.A., Wu, M. and Lander, G.C.  Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California 92037, USA  
References: bioRxiv (2017) 
DOI: 10.1101/141994
Date: May 2017
Abstract
Title: Achieving Better Than 3 Å Resolution By Single Particle Cryo-EM At 200 keV
Authors: Herzik, M.A., Wu, M. and Lander, G.C.  Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California 92037, USA  
References: bioRxiv (2017) 
DOI: 10.1101/141994
Date: May 2017
Abstract: Technical and methodological advances in single-particle cryo-electron microscopy (cryo-EM) have expanded the technique into a resolution regime that was previously only attainable by X-ray crystallography. Although single-particle cryo-EM has proven to be a useful technique for determining the structures of biomedically relevant molecules at near-atomic resolution, nearly 98% of the structures resolved to better than 4 Å resolution have been determined using 300 keV transmission electron microscopes (TEMs). We demonstrate that it is possible to obtain cryo-EM reconstructions of macromolecular complexes at a range of sizes to better than 3 Å resolution using a 200 keV TEM. These structures are of sufficient quality to unambiguously assign amino acid rotameric conformations and identify ordered water molecules, features previously thought only to be resolvable using TEMs operating at 300 keV.    Comments: open access (CC BY 4.0), preprint, non-peer reviewed; Thermo Scientific™ Talos Arctica, Gatan K2 Summit, Leginon
 

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