VolumeScope SEM for Life Sciences

Highest quality isotropic 3D data from large sample volumes

The Thermo Scientific VolumeScope™ scanning electron microscope (SEM) is a novel serial block-face imaging solution that enables excellent z-resolution from Multi-Energy Deconvolution SEM combined with the efficiency of in situ sectioning. The VolumeScope SEM unravels the complex 3D architecture of cells and tissues in their natural context, which is crucial for gaining understanding of the structure function correlation in biological systems. The VolumeScope SEM's automation and ease-of-use increase the productivity of operators of varying levels of expertise, allowing for acquisition of large sample volumes at isotropic resolution.

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Key Benefits

Truly isotropic 3D data from large volumes:
Excellent z-resolution from Multi-Energy Deconvolution SEM combined with the efficiency of in situ sectioning.

Highest contrast and resolution on all samples:
Highest contrast and optimal SNR with in-lens and in-column detectors for HiVac, as well as dedicated detectors for optimal resolution in LoVac.

Simple switch between normal SEM use and serial block face imaging:
Compact, stage-mounted microtome allowing easy exchange.

Instant productivity for all operators:
High degree of automation and design for ease-of-use adding to operator efficiency and inspiring greater experimentation.

Increased efficiency and accuracy thanks to workflow solutions:
Fast identification of regions of interest by CLEM approaches and large volume coverage with automated multi-tile set runs.

Featured Video

The VolumeScope™ SEM

Learn how our VolumeScope improves large-volume SEM by combining serial block-face imaging with Multi-Energy Deconvolution.

Featured Webcast

On-Demand Webcast : A Complete Serial Block Face Imaging workflow using integrated hardware and software

The unique integration of Amira software with the Thermo Scientific VolumeScope™ SEM provides for a truly seamless workflow. Our exclusive webcast presents a complete analysis workflow of biological tissues using only our tools, from sample preparation through image acquisition, visualization, and quantification.

Featured Document

The VolumeScope SEM Datasheet

VolumeScope is a novel Serial Block Face Imaging solution that combines mechanical and optical sectioning using our proprietary Multi-Energy Deconvolution technology to facilitate automated acquisition of large sample volumes at isotropic resolution.

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Application Examples

Imaging of challenging samples is possible with a dedicated low-vacuum imaging detector. No charging artifacts present, as shown in this mouse kidney tissue.

Challenge of Serial Block Face Imaging (SBFI); High vacuum imaging of resin embedded tissue. Arrow heads showing charging artifacts.

Nominal isotropic resolution of 10x10x10nm (x,y,z), 222 slices (physical + optical) @ 30nm (nominal thickness of a physical cut), volume of 20um x 17um x 2.2μm. Sample: Jean-Marc Verbavatz, MPI of Molecular Cell Biology and Genetics, Germany.

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