Courtesy: Robert L. Duda (a), Matthijn Vos (b) and James F. Conway (a); a. University of Pittsburgh; b. Thermo Fisher Scientific
The Challenges of Protein Complex Analysis
Drug development at the pace requested by today's society requires the study of molecular mechanisms as close as possible to
at high resolution. Until recently, the main technique available to achieve high resolution structures of biological molecules was crystallography.
2015 Method of the Year, is now able to solve near-atomic-resolution structures with volume and clarity. Using Cryo-EM to understand molecular structures such as proteins, protein complexes, and protein-ribonucleic acid associations-the fundamental building blocks of life-will lead to wide scale pharmaceutical solutions for treating diseases and disorders.