Life Sciences Applications

Electron microscopy is used in research laboratories to explore the molecular mechanisms of disease, to visualize the 3D architecture of tissues and cells, to determine the conformation of flexible protein structures and complexes, and to observe individual viruses and macromolecular complexes in their natural biological context.

Understanding cell structure and function is essential to pushing the boundaries of discovery. Whether working in cancer, HIV, genetic, or drug discovery research, scientists need to know how diseases or genetic defects affect cells and how cells respond. With deeper understanding, treatments can be developed to more effectively fight disease and aging. However, no single technology can provide all answers, so a broad range of technology innovation is needed to move scientists from questions to answers.

Workflow and application solutions

FEI’s industry-leading life sciences workflow solutions including single particle analysis, cryo-tomography, and large volume analysis offer a proven path to results for structural and cell biology researchers. Our comprehensive range of hardware and software allows researchers at any level to move from questions to answers more efficiently.

Scanning Electron Microscopes

Scanning Electron Microscopes (SEMs) have become important instruments for cellular and structural biology applications. Recent technological innovations now allow for very low-voltage operation on sensitive samples while retaining the high contrast and resolution researchers need to understand the key functions and processes of organelles. Our SEM instruments are used in many research applications including:

  • Large volume analysis
  • 3D Tissue Imaging
  • Biological pathways
  • Biomarkers
  • Cellular organization and morphology
  • Correlative Microscopy
Teneo VS SEM
Teneo VS SEM is the first Serial Block Face imaging solution combining physical sectioning with FEI proprietary virtual slicing method to enable automated acquisition of large volumes with dramatically improved axial resolution.
Verios XHR SEM
The Verios™ 460 XHR is the second generation of FEI’s leading XHR SEM family. It provides sub-nanometer resolution from 500eV to 30 keV and enhanced contrast needed for precise measurements on materials in advanced semiconductor manufacturing, Life - & Materials Science applications, and low beam currents for delicate biological samples in Life Sciences.

DualBeam Microscopes

DualBeam Focused Ion Beam-Scanning Electron Microscope systems (FIB-SEMs) feature outstanding 2D and 3D performance on a broad range of samples, including very sensitive materials. Additionally, DualBeam FIB-SEMs are capable of preparing ultra-thin samples for S/TEM, TEM, and cryo-EM applications. These instruments are used in many research applications including:

  • Cryo-tomography
  • 3D cellular ultrastructure and architecture
  • Macromolecular localization
  • Cell-to-cell interfacing
  • Surface morphology
  • Host-pathogen interactions
  • Pathology & medical diagnostics
  • Cellular tomography
  • Toxicology
  • Viral load monitoring
  • Pharmaceutical quality control
Scios
The Scios™ is FEI's newest DualBeam featuring an electron column specifically designed to perform high throughput two-dimensional (2D) and three-dimensional (3D) characterization of all materials, including insulating or magnetic materials. It also includes the new Trinity™ detector suite, comprising of three highly-efficient, in-lens detectors, offering the broadest range of sample information simultaneously. The Focused Ion Beam enables site specific, fast milling of highest quality, ultra thin lamella to meet any S/TEM application requirement.

Transmission Electron Microscopes

Transmission Electron Microscopes (TEMs) feature the highest resolution for the 2D and 3D characterization of biological samples. TEMs are powerful and flexible enough to perform cryo-tomography, single particle analysis, 2D electron crystallography, and more. High levels of automation add to the increased throughput of these instruments. These instruments are used in many research applications including:

  • Single Particle Analysis
  • Cryo fixation
  • Dual-axis tomography
  • Single particle analysis Template matching
  • 2D electron crystallography
  • Pathology and Medical diagnostics
Titan Krios
The Titan Krios is the most powerful and flexible high resolution electron microscope for 2D and 3D characterization of protein structures and protein complexes. With automated sample loading and reliable unattended operation, Titan Krios achieves a level of productivity that is unmatched.
Talos L120C
An ideal entry-level solution for imaging and tomography that can be configured as a basic cryo-TEM imaging platform. Fully upgradeable, the FEI Talos L120C will meet your needs, whether those needs are in Cryo or Room Temperature or 2D imaging or 3D imaging and multi-modality imaging experiments.
Talos Arctica
The Talos™ Arctica is a 200kV FEG Transmission and Scanning Electron Microscope (STEM). It is a powerful, stable, and versatile system for delivering high-resolution 3D characterization of biological and biomaterials samples in cell biology, structural biology, and nanotechnology research. Talos enables scientists to quickly obtain better insight and understanding of macromolecular structures, cellular components, cells, and tissues in three dimensions.
Titan Halo
Effective biological imaging at the nanoscale requires platforms which are able to take the lowest contrast, sensitive and valuable sample and turn it into revealing, insightful data. Titan Halo excels at delivering application versatility and flexibility without any compromise to optical stability.
Talos
TalosTM is a 200kV S/TEM designed for fast, precise and quantitative characterization of nanomaterials in multiple dimensions. It accelerates materials nanoanalysis based on higher data quality, faster acquisition, simplified, easy and automated operation.