Association of cancer and myeloid cells
Courtesy of Dr. Rita Serda
Immune surveillance by macrophages and monocytes is important for removing foreign invaders from the body, eliminating dead or damaged cells, and tissue homeostasis. Functional plasticity of macrophages enables them to respond to different stimuli, performing a variety of immune modulatory roles. During tumor development, macrophages are among the first immune cells to migrate into the tumor. Stimuli, including molecules secreted by cancer cells, polarize macrophages into various tumor-associated macrophage subpopulations. Factors secreted by macrophages include immunosuppressive cytokines, inflammatory chemokines, and phagocytosis molecules. Shown here are multiple macrophages (white) associating with a breast cancer cell (red). At the University of New Mexico, we are using nanotechnology to deliver agents that influence immune cells to actively participate in destroying tumor cells.
Voltage: 20 kV
Horizontal Field Width: 20 um
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