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Transmission Electron Microscope

Glacios Cryo-TEM for Life Sciences

Single particle screening and data acquisition made easy

The Thermo Scientific™ Glacios™ Cryo Transmission Electron Microscope (Cryo-TEM) delivers a complete and affordable cryo-EM solution to a broad range of scientists. The Glacios Cryo-TEM features the same innovative automation for ease of use as found on the Thermo Scientific™ Krios™ G3i Cryo-TEM, and it bundles it into a small footprint that simplifies installation.




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Providing an entry path into cryo-EM

The Glacios Cryo-TEM delivers a high-performance cryo-EM solution to a broader range of scientists. Incorporating the knowledge gleaned from more than a decade of technical leadership in cryo-EM, the breakthrough Glacios Cryo-TEM extends the accessibility of cryo-EM with innovative automation for ease of use and a small footprint that simplifies installation—all of which are essential to more industrial applications, such as pharmaceutical drug discovery and development. 

Key Benefits

Automated sample screening

For a successful cryo-EM experiment, it is mandatory that the sample is of optimal quality prior to loading into the microscope. For both biochemistry and vitrification, the optimal quality parameters must be determined, requiring an efficient screening process. The Glacios Cryo-TEM features software that can automatically screen a batch of samples, storing grid overviews as well as a quality assessment of specific areas of interest on the samples.

Workflow connectivity

The Krios G3i and Glacios Cryo-TEMs are designed to be integrated together in an SPA workflow, prescreening samples in the Glacios Cryo-TEM before imaging them at high-resolution in the Krios G3i Cryo-TEM. Designed-in connectivity between the Glacios Cryo-TEM and the Krios G3i Cryo-TEM not only enhances the efficiency of the pre-screening process for facilities that have a Krios G3i Cryo-TEM, but also provides a pathway to higher-resolution imaging for Glacios Cryo-TEM-based laboratories by permitting them to pass samples directly to a Krios G3i Cryo-TEM at another location for additional analysis.

Increased productivity of the SPA workflow

The Krios G3i and Glacios Cryo-TEMs are designed to be integrated together in an SPA workflow, prescreening samples in the Glacios before imaging them at high-resolution in the Krios. Designed-in connectivity between the Glacios and the Krios not only enhances the efficiency of the pre-screening process for facilities that have a Krios, but also provides a pathway to higher-resolution imaging for Glacios-based laboratories by permitting them to pass samples directly to a Krios at another location for additional analysis.

Enhanced automation and ease of use

Structural biologists prefer to focus on obtaining answers to biologically relevant questions rather than spending time on learning tedious optical alignment processes. The Glacios Cryo-TEM reduces the number of complex alignments that normally need to be performed. For recurring alignments that need to be done regularly (i.e. auto-coma and auto-stigmate), automated alignment routines have been implemented into the EPU software. This level of automation goes a long way toward making the structural analysis of proteins, protein complexes, and other biomolecular structures faster, easier, and more accessible than ever before.

Optimal tool performance

The Glacios Cryo-TEM features a self-assessment function that automatically evaulates the optical status of the microscope, providing feedback for any steps that require optimization. Additionally, automated alignment routines allow the instrument to be tuned to its optimal starting point for SPA or tomography experiments.

Featured Document

Glacios Cryo-TEM Datasheet

Adopt cryo-electron microscopy with improved ease-of-use and a high level of automation.

Learn more about the new Thermo Scientific™ Glacios™ Cryo-Transmission Electron Microscope (Cryo-TEM), a complete cryo-EM solution. It features 200 kV X-FEG optics, the industry-leading Autoloader for cryogenic sample manipulation, and innovative automation for ease of use, all bundled into a small footprint that simplifies installation.

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