Structural Mechanism of Trimeric HIV-1 Envelope Glycoprotein Activation
HIV-1 infection begins with the binding of trimeric viral envelope glycoproteins (Env) to CD4 and a co-receptor on target Tcells. Understanding how these ligands influence the structure of Env is of fundamental interest for HIV vaccine development. Using cryo-electron microscopy, we describe the contrasting structural outcomes of trimeric Env binding to soluble CD4, to the broadly neutralizing, CD4-binding site antibodies VRC01, VRC03 and b12, or to the monoclonal antibody 17b, a co-receptor mimic.
Please provide or confirm your information to download your document.
Your document has been downloaded. You will be taken back to your previous page in 4 seconds or
to go now.