Cellular tomography involves examining the cellular structures in all three dimensions to generate an accurate three-dimensional map of the interior of the cell. It enables researchers to analyze molecular structures in relation to the cellular architecture, the cytoskeleton and the cell organelles. Most proteins do not function as individual entities, but in coordination or dependence with other proteins. The knowledge of the three-dimensional organization is essential to understand protein function at the cellular level.
Cellular tomography using transmission electron microscopy (TEM) is the only available technology to chart the inside of a cell and is therefore an essential technology in the cell biologists' tool box.
Microscopes for Cellular Tomography:
Accessories for Cellular Tomography: